Dihydropyridines as potent calcium channel blockers in neuronal cells

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Nicardipine, one of the dihydropyridine derivatives, in a nanomolar concentration range suppressed the high K+-induced neurotransmitter from cultured neuronal cells (chick embryonic neural retina cells and clonal rat pheochromocytoma cells). The high K+-induced Ca2+ uptake into pheochromocytoma cell was also blocked by nicardipine in the same concentration range. [3H]Nitrendipine, another dihydropyridine derivative, bound specifically to pheochromocytoma cell homogenate in a saturable manner. We concluded that dihydropyridines block and bind to the high K+-sensitive Ca2+ channels in neuronal cells. © 1983.




Takahashi, M., & Ogura, A. (1983). Dihydropyridines as potent calcium channel blockers in neuronal cells. FEBS Letters, 152(2), 191–194. https://doi.org/10.1016/0014-5793(83)80377-9

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