Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome

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Abstract

Objective: To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). Design: Prospective study in normal and PCOS women. Setting: General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital. Patient(s): Six normal women and five women with PCOS. Intervention(s): Administration of diazoxide to lower circulating insulin concentrations. Main Outcome Measure(s): Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy. Result(s): Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS. Conclusion(s): Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion. © 2007 American Society for Reproductive Medicine.

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Evans, W. S., Taylor, A. E., Boyd, D. G., Johnson, M. L., Matt, D. W., Jimenez, Y., & Nestler, J. E. (2007). Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome. Fertility and Sterility, 88(1), 118–124. https://doi.org/10.1016/j.fertnstert.2006.11.109

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