With improving measures to prevent vertical transmission of HIV and an expanding population of young adults acquiring HIV, the population of HIV-exposed uninfected (HEU) infants is increasing. This group is at higher risk for infectious morbidity than the general population. Obvious reasons include a higher prevalence of infectious diseases such as tuberculosis in the household and illness in the parents affecting care & family integrity. HIV exposure, itself might affect the immune system and formula feeding can exacerbate gastro-intestinal infections.
Cotton, M. F. (2014). Infections in HIV-exposed uninfected infants: Under-appreciated but a growing concern. International Journal of Infectious Diseases, 21, 68. https://doi.org/10.1016/j.ijid.2014.03.565