The role of TNF- α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease

21Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

Abstract

Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is characterized by multiple steps: inflammation, fibrosis, and calcification. Numerous studies focalized on its physiopathology highlighting different "actors" for the multiple "acts." This paper focuses on the role of the tumor necrosis factor superfamily (TNFSF) members in the pathogenesis of CAVD. In particular, we discuss the clinical and experimental studies providing evidence of the involvement of tumor necrosis factor-alpha (TNF-α), receptor activator of nuclear factor-kappa B (NF-B) ligand (RANKL), its membrane receptor RANK and its decoy receptor osteoprotegerin (OPG), and TNF-related apoptosis-inducing ligand (TRAIL) in valvular calcification. © 2013 Antonella Galeone et al.

Cite

CITATION STYLE

APA

Galeone, A., Paparella, D., Colucci, S., Grano, M., & Brunetti, G. (2013). The role of TNF- α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease. The Scientific World Journal. Hindawi Publishing Corporation. https://doi.org/10.1155/2013/875363

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free