Responsive molecular designs to specific biosignals in microenvironments endow site-specific functionalities with associated polymers. Thus, the construction of small interfering RNA (siRNA) carriers with functional polymers enables smart programs that are triggered by sequential biosignals in a pathway to the targeted cytosol for effective gene silencing. In this review, we explain rational strategies for the design of functional polymers with responsiveness to biosignals and describe the examples of smart carriers for siRNA delivery.
Takemoto, H., & Nishiyama, N. (2017). Functional polymer-based siRNA delivery carrier that recognizes site-specific biosignals. Journal of Controlled Release, 267, 90–99. https://doi.org/10.1016/j.jconrel.2017.09.005