Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

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Abstract

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. © 2011 Elsevier Ltd.

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De Oliveira, J. C., Scrideli, C. A., Brassesco, M. S., Morales, A. G., Pezuk, J. A., Queiroz, R. de P., … Tone, L. G. (2012). Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features. Leukemia Research, 36(3), 293–298. https://doi.org/10.1016/j.leukres.2011.10.005

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