The goal of this work is to develop an impedimetric aptasensor sensitive, selective and stable for detection of thrombin. Thiol modified aptamer sequence being grafted on gold electrode, the faradic electrochemical impedance measurements allow the direct detection of thrombin in the range of 3.1-200 ngmL -1 with a detection limit of 3.1 ngmL -1 (80 fM). This study demonstrates that these aptasensors exhibit high sensitivity, high selectivity (compared to a model protein, BSA), stability and reproducibility. © 2011 Published by Elsevier Ltd.
Meini, N., Farre, C., Chaix, C., Kherrat, K., Dzyadevych, S., & Jaffrezic-Renault, N. (2011). Impedimetric aptasensor for thrombin detection. In Procedia Engineering (Vol. 25, pp. 1461–1464). https://doi.org/10.1016/j.proeng.2011.12.361