A Potential New Alzheimer’s Treatment That May Function by Modulating the Gut Microbiota

Abstract

Alzheimer’s disease (AD) is the most common form of dementia, and causes a progressive decline in memory, language, executive and visuospatial function, personality, and behaviour. For many years, there have been only four approved medications to help improve cognition in patients with AD, but these only address the symptoms, and do not affect the course of the underlying disease. Here we discuss information presented at the 13th and 14th Clinical Trials on Alzheimer’s Disease conferences about the GREEN MEMORY trial (NCT04520412) of GV-971® (sodium oligomannate). This treatment, as well as the recently approved aducanumab, provides hope that new therapeutics with novel mechanisms of action may provide disease-modifying effects and help slow disease progression in people with AD.