Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

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Abstract

FGL1 is identified as a major ligand for the inhibitory receptor LAG-3, and its blockade can potentiate anti-tumor T cell responses.

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Wang, J., Sanmamed, M. F., Datar, I., Su, T. T., Ji, L., Sun, J., … Chen, L. (2019). Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 176(1–2), 334-347.e12. https://doi.org/10.1016/j.cell.2018.11.010

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