Lung injury and surfactant metabolism after hyperventilation of premature lambs

53Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We asked whether lung injury and surfactant metabolism differed in preterm lambs after a 1-h period of hyperventilation to PCO2 values of 25-30 mm Hg. The lambs then were surfactant treated and conventionally ventilated (CV) or high-frequency oscillatory ventilated (HFOV) for an additional 1 or 8 h. The results were compared with lambs that were not hyperventilated or surfactant treated but were ventilated with CV or HFOV. The 1-h hyperventilation resulted in increased alveolar protein, increased recovery of intravascular [131I]albumin in the lungs, and an increase in tumor necrosis factor-α mRNA. There were no differences between CV or HFOV in alveolar or total lung recoveries of saturated phosphatidylcholine (Sat PC), tracer doses of [14C]Sat PC and [125I]surfactant protein-B, or in percent Sat PC in large aggregate surfactant in surfactant-treated lambs. The lambs not hyperventilated or treated with surfactant had lower large aggregate pools and lower recoveries of [14C]Sat PC and [125I]surfactant protein-B in total lungs than for the surfactant-treated lungs, but there were no differences between the CV and HFOV groups. Hyperventilation followed by surfactant treatment resulted in a mild injury, but the subsequent use of CV or HFOV did not result in differences in surfactant metabolism.

Cite

CITATION STYLE

APA

Ikegami, M., Kallapur, S., Michna, J., & Jobe, A. H. (2000). Lung injury and surfactant metabolism after hyperventilation of premature lambs. Pediatric Research, 47(3), 398–404. https://doi.org/10.1203/00006450-200003000-00019

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free