Vitamin D associations with renal, bone, and cardiovascular phenotypes: African American-diabetes heart study

Abstract

Context: Vitamin D binding protein (DBP) is an important determinant of bioavailable Vitamin D (BAVD) and may provide clues to racial variation in osteoporosis and atherosclerosis. Objective: The objective was to assess relationships between DBP, BAVD, 25-hydroxyVitamin D (25OHD),and1,25 di-hydroxyvitaminD(1,25OH2D) with kidney, bone, adipose,andatherosclerosis phenotypes in African Americans with type 2 diabetes. Design: Cross-sectional (N = 545) and longitudinal (N = 288; mean 5.1 ± 0.9-year follow-up) relationships between Vitamin D concentrations with renal phenotypes, vertebral bone mineral density, aorto-iliac, coronary artery, and carotid artery calcified plaque (CP), and adipose tissue volumes were studied. Setting: African American-Diabetes Heart Study. Patients: Participants were 56.7% female with mean±standard deviation (SD) age 55.6±9.6 years, diabetes duration 10.3 ± 8.2 years, and eGFR 90.9 ± 22.1 ml/min/1.73 m2. Interventions: None. Main Outcomes and Measures: Associations tested between Vitamin D and the previously mentioned phenotypes adjusting for age, sex, African ancestry proportion, diabetes duration, statins, smoking, changes in estimated glomerular filtration rate, body mass index, hemoglobin A1c, and blood pressure. Results: 1,25OH2D was inversely associated with change in coronary artery CP (parameter estimate [β] μ0.005, standard error [SE] 0.002; P = .037), with a trend for change in carotid artery CP (β μ0.007, SE 0.004; P = .074). Further adjustment for renin-aldosterone-system blockade revealed inverse association between 1,25OH2D and change in albuminuria (β μ0.004, SE 0.002; P = .037). DBP, BAVD, and 25OHD did not associate significantly with changes in albuminuria, CP, or bone mineral density. BAVD was inversely associated with visceral, subcutaneous, intermuscular, and pericardial adipose volumes. Conclusions: In contrast toBAVDand 25OHD, only 1,25OH2Dlevels were significantly and inversely associated with changes in subclinical atherosclerosis and albuminuria in African Americans, suggesting potential beneficial effects.