Perfectionism mediated the relationship between brain structure variation and negative emotion in a nonclinical sample

Abstract

In maladaptive respects, perfectionism reflects an individual’s concern over making mistakes and doubting the quality of his or her own actions excessively, which would affect one’s emotion. However, little is known about the neural mechanisms associated with the perfectionism and negative affect. In this study, voxel-based morphometry was performed to identify the brain regions underlying individual differences in perfectionism, which was measured by the Chinese Frost Multidimensional Perfectionism Scale (CFMPS), in a large sample of nonclinical young adults. Our results showed that the two subdimensions of the perfectionism, concern over mistakes (CM) and doubts about actions (DA), were both positively correlated with the self-reported anxiety and depression as well as the gray matter volume (GMV) in the anterior cingulate cortex (ACC), a pivotal brain region in cognitive control, affective state, and regulation. Moreover, CM, DA, and organization scores were respectively correlated with distributed brain regions involved in multiple cognitive and emotion processes. Our results furthermore revealed that the score of DA acted a mediational mechanism underlying the relationship between the GMV of ACC and self-rating negative affect (anxiety and depression). Taken together, these results might suggest the neuroanatomical basis of perfectionism and the association among the perfectionism, negative emotion, and brain architecture. This study emphasized that perfectionism could play a crucial role in the arousal of negative affect.