Fluid dynamics model of mitral valve flow: Description with in vitro validation

76Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

A lumped variable fluid dynamics model of mitral valve blood flow is described that is applicable to both Doppler echocardiography and invasive hemodynamic measurement. Given left atrial and ventricular compliance, initial pressures and mitral valve impedance, the model predicts the time course of mitral flow and atrial and ventricular pressure. The predictions of this mathematic formulation have been tested in an in vitro analog of the left heart in which mitral valve area and atrial and ventricular compliance can be accurately controlled. For the situation of constant chamber compliance, transmitral gradient is predicted to decay as a parabolic curve, and this has been confirmed in the in vitro model with r > 0.99 in all cases for a range of orifice area from 0.3 to 3.0 cm2, initial pressure gradient from 2.4 to 14.2 mm Hg and net chamber compliance from 16 to 29 cc/mm Hg. This mathematic formulation of transmitral flow should help to unify the Doppler echocardiographic and catheterization assessment of mitral stenosis and left ventricular diastolic dysfunction. © 1989.

Cite

CITATION STYLE

APA

Thomas, J. D., & Weyman, A. E. (1989). Fluid dynamics model of mitral valve flow: Description with in vitro validation. Journal of the American College of Cardiology, 13(1), 221–233. https://doi.org/10.1016/0735-1097(89)90575-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free