Hormones restore biomechanical properties of the vagina and supportive tissues after surgical menopause in young rats

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Abstract

Objective: The objective of the study was to determine the impact of hormones on the biomechanical properties of the vagina and its supportive tissues following surgical menopause in young vs middle-aged rats. Study Design: Long-Evans rats (4-month virgin [n = 34], 4-month parous [n = 36], and 9-month parous [n = 34]), underwent ovariectomy (OVX) or sham surgery. OVX animals received hormones (estrogen [E2] or estrogen plus progesterone [E2 plus P4]), placebo, or a matrix metalloproteinase inhibitor (chemically modified tetracycline-8 [CMT-8]). Animals were euthanized after 8 weeks and the biomechanical properties of the vagina and supportive tissues determined. Data were analyzed using a 1-way analysis of variance and posthoc tests. Results: OVX induced a rapid decline in the biomechanical properties of pelvic tissues in young but not middle-aged rats. Supplementation with E2, E2 plus P4, or CMT-8 restored tissues of young rats to control levels with no effect on middle-aged tissues. Parity did not have an impact on tissue behavior. Conclusion: OVX has a differential effect on the tissues of young vs middle-aged rats. © 2008 Mosby, Inc. All rights reserved.

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Moalli, P. A., Debes, K. M., Meyn, L. A., Howden, N. S., & Abramowitch, S. D. (2008). Hormones restore biomechanical properties of the vagina and supportive tissues after surgical menopause in young rats. American Journal of Obstetrics and Gynecology, 199(2), 161.e1-161.e8. https://doi.org/10.1016/j.ajog.2008.01.042

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