Objective: To evaluate the effectiveness of topical application of aspirin in chloroform as an adjuvant in the management of chronic neurogenic pain. Design: Intervention study, nonrandomized before-and-after trial. Setting: A department of physical medicine and rehabilitation in a tertiary care university leaching hospital. Participants: Fifteen adults who presented with severe, chronic neurogenic pain in whom conventional methods of treatment were unsuccessful in alleviating the pain. Intervention: A solution of aspirin (acetyl salicylic acid) in chloroform was applied over the painful areas. Main Outcome Measures: A numerical scale from 0 to 100 was used to measure the severity of pain. Results: Seventy-four percent of patients showed a good response, 13% had fair response, and in 13% there was no response. Conclusion: Aspirin in chloroform solution is a simple and effective adjuvant in the management of chronic neurogenic pain.
Tharion, G., & Bhattacharji, S. (1997). Aspirin in chloroform as an effective adjuvant in the management of chronic neurogenic pain. Archives of Physical Medicine and Rehabilitation, 78(4), 437–439. https://doi.org/10.1016/S0003-9993(97)90238-0