Enantioselective synthesis of both enantiomers of dimethyl cis-(4-acetoxycyclopent-2-enyl)malonate, key intermediates for epijasmonate

Abstract

Both enantiomers (3 and 4) of dimethyl cis-(4-acetoxycyclopent-2-enyl)malonate (3), known intermediates for the synthesis of epijasmonate, were prepared in an enantio-enriched form from common starting material 2 based on desymmetrization of the meso-character by palladium-catalyzed asymmetric allylic alkylation. © 2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry.