Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

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Abstract

Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes. Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. and Raud et al. now report that LC-FAO is largely dispensable for these processes.

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Van den Bossche, J., & van der Windt, G. J. W. (2018, October 2). Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment? Cell Metabolism. Cell Press. https://doi.org/10.1016/j.cmet.2018.09.018

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