Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

Abstract

Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes. Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. and Raud et al. now report that LC-FAO is largely dispensable for these processes.