Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots

13Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and characterized by spectroscopic techniques (NMR of 1H, 13C and IR). The in vitro antiproliferative activity of jatrophone showed selectivity in a concentration dependent way with Total Inhibition growth of: glioma 0.57 μg mL-1 (U251), breast cancer 9.2 μg mL-1 (MCF-7), adriamycin-resistant ovarian cancer 0.96 μg mL-1 (NCI-ADR/RES), kidney 4.2 μg mL-1 (786-0), prostate cancer 8.4 μg mL-1 (PC-3), colon cancer 16.1 μg mL-1 (HT29) and leukemia 0.21 μg mL-1 (K-562).

Cite

CITATION STYLE

APA

de Fernandes, E. S., Rodrigues, F. A., Tófoli, D., Imamura, P. M., de Carvalho, J. E., Ruiz, A. L. T. G., … Silva, R. C. L. (2013). Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots. Revista Brasileira de Farmacognosia, 23(3), 441–446. https://doi.org/10.1590/S0102-695X2013005000026

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free