Effect of pore former on the properties of casted film prepared from blends of Eudragit® NE 30 D and Eudragit® L 30 D-55

Abstract

The casted films of aqueous dispersions of Eudragit® NE30 D and Eudragit® L30 D-55 containing pore former were prepared. The study investigated the influence of pore former on basic model drug clarithromycin release, water uptake and water vapor permeability from casted film prepared from the blends of neutral polymer dispersion of Eudragit® NE30 D and enteric polymer dispersion of Eudragit® L30 D-55. This study was concluded that pore former hydroxypropyl methyl cellulose, lactose, polyethylene glycol (PEG) and polyvinyl pyrrolidon (PVP) was released at the beginning of the release process, the rate and extent of water uptake of the polymeric films were much higher in phosphate buffer pH 6.8 than in pH 5.0 and the concentration of pore former have a significant influence on the permeability to water vapour. © 2007 Pharmaceutical Society of Japan.