Improving performance of reflectance diffuse optical imaging using a multicentered mode

Abstract

We propose a novel multicentered mode for arrangement of, optical fibers to improve the imaging performance of reflectance diffuse optical imaging (rDOI). Simulations performed using a semiinfinite model show that the proposed multicentered geometries can achieve a maximum of 42 overlapping measurements. The contrastto-noise ratio (CNR) analysis indicates that the best spatial resolution is 1 mm in radius and the contrast resolution is less than 1.05 for the multicentered geometries. The results from simulations indicate significant improvement in image quality compared to the singlecentered mode and previous geometries. Additional experimental results on a single human subject lead to the conclusion that the proposed multicentered geometries are appropriate for exploring activations in the human brain. From the results of this research, we conclude that the proposed multicentered mode could advance the performance of rDOI both in image quality and practical convenience. © 2006 Society of Photo-Optical Instrumentation Engineers.