In a long term experiment laboratory mice were selected for high (line DU-hTP) or low (line DU-ITP) paternal treadmill Performance to differentiate the endurance fitness. In generation 54 six enzymes and seven Substrates were investigated in the blood plasma of males and females in DU-hTP (n Combining double low line 104) and DU-ITP (n Combining double low line 141). Compared with line DU-ITP in line DU-hTP significantly higher enzyme activities, increased glucose concentration and lower level of triglycerides were found. The components of total cholesterol were divergent between the two lines and positively effected in DU-hTP for higher HDL-cholesterol. Animals with high endurance fitness showed a higher gain in the HDL-cholesterol concentration with increased total cholesterol level in the blood than gain of LDL + VLDL-cholesterol concentration.
Falkenberg, H., Langhammer, M., & Renne, U. (2000). Comparison of biochemical blood traits after long-Term selection on high or low locomotory activity in mice. Archives Animal Breeding, 43(5), 513–522. https://doi.org/10.5194/aab-43-513-2000