Identification of three novel in vivo-induced expressed antigens during infection with Streptococcus suis serotype 2

13Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Streptococcus suis serotype 2 (SS2) is a porcine and human pathogen with adhesive and invasive properties. The shortage of studies on the pathogenesis mechanisms of SS2 has made it very difficult to control infection with this pathogen. Three novel in vivo-induced antigens were identified using serological proteome analysis of the SS2 cell wall-associated proteins - SecA, autolysin and ZnuA - the upregulation of which in vivo relative to in vitro was shown by real-time PCR analysis. The in vivo-induced expression of znuA was also confirmed by the fact that the purified recombinant ZnuA could be recognized not by hyperimmune sera but by convalescent sera. This is, to the best of the authors' knowledge, the first report using an immunoproteomic method to identify in vivo-induced antigens of SS2. © 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Author supplied keywords

Cite

CITATION STYLE

APA

Zhang, A., Chen, B., Mu, X., Zhao, Y., Zheng, P., Chen, H., & Jin, M. (2009). Identification of three novel in vivo-induced expressed antigens during infection with Streptococcus suis serotype 2. FEMS Microbiology Letters, 295(1), 17–22. https://doi.org/10.1111/j.1574-6968.2009.01574.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free