Revertant Mosaicism — Patchwork in the Skin

Abstract

from animal models provides further support for the idea that paracrine interactions may also attract nontumor (e.g., bone marrow–derived) and tumor cells to establish a premetastatic niche. 2,3 The ac-tive dysadhesion of local tissues to allow tumor-cell invasion (e.g., via E-cadherin, dysadherin, or both) is also probably triggered by paracrine sig-naling, as Batistatou et al. point out. Finally, the complex roles played by the host-site microenviron-ment and by the immune system in metastatic dormancy are not yet fully understood, although recent intriguing results point to tumor-specific T-cell suppression of multistage carcinogenesis through cytokine signaling. 4