Food-specific IgE is central to the pathobiology of food allergy, but not sufficient to induce disease. Chen et al. (2015) demonstrate that food-elicited reactions require an immature mast cell that generates IL-9 to induce its own maturation.
Barrett, N. A., & Austen, K. F. (2015, October 20). Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis. Immunity. Cell Press. https://doi.org/10.1016/j.immuni.2015.09.011