Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28

5Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Anglerfish somatostatin-14 (SS-14) and somatostatin-28 (aSS-28) are derived from pro-somatostatin I (aPSS-I) and pro-somatostatin II (PSS-II), respectively. Purified yeast aspartic protease 3 (YAP3), was shown to cleave aPSS-I at the Arg18-Lys82 to yield SS-14 and Lys-1SS-H. In contrast, YAP3 cleaved aPSS-II only at the monobasic residue. Arg73 to yield aSS-28. Since the paired basic and monobasic sites are present in both precursors, the results indicate that the structure and conformation of these substrates dictate where cleavage occurs. Furthermore, the data show that YAP3 has specificity for both monobasic and paired basic residues. © 1993.

Cite

CITATION STYLE

APA

Cawley, N. X., Noe, B. D., & Loh, Y. P. (1993). Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28. FEBS Letters, 332(3), 273–276. https://doi.org/10.1016/0014-5793(93)80648-E

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free