Bone marrow-derived cells have an important role in tumor metastasis and have been reported to "prime" distant tissues for tumor engraftment, although the mechanisms for their recruitment have remained unclear. A new study by Hiratsuka et al. describes an inflammatory signaling pathway that mediates the chemoattraction of myeloid and tumor cells to organ-specific metastatic sites. © 2008 Elsevier Inc. All rights reserved.
Peinado, H., Rafii, S., & Lyden, D. (2008, November 4). Inflammation Joins the “Niche.” Cancer Cell. https://doi.org/10.1016/j.ccr.2008.10.012