GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB

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Abstract

Two interlinked quorum sensing circuits, las and rhl, which control pathogenesis of Pseudomonas aeruginosa are further modulated by numerous regulators, including VqsR (virulence and quorum sensing regulator). High-density oligonucleotide microarrays were used to compare the global expression profile of a wild-type and VqsR mutant in ABC minimal medium. The expression of a large group of metabolic genes, ECF sigma factors as well as of many quorum-sensing genes previously not assigned to VqsR-regulon was found to be affected by the disruption of vqsR. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

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Juhas, M., Wiehlmann, L., Salunkhe, P., Lauber, J., Buer, J., & Tümmler, B. (2005). GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB. FEMS Microbiology Letters, 242(2), 287–295. https://doi.org/10.1016/j.femsle.2004.11.020

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