Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children

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Abstract

Objective: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. Methods: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa-MG. Anthropometric and body composition assessment, as well as biochemical profile of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire. Results: Many children had excess weight (35.2%), abdominal adiposity (10.5%), and body fat (15.6%), as well as increased ApoB/ApoA1 ratio (14.7%), total cholesterol (51.8%), and triglycerides (19.8%). Children with excess weight and total and central fat had a higher prevalence of having a higher ApoB/ApoA1 ratio, as well as those with atherogenic lipid profile (increased LDL-c and triglycerides and low HDL-c). A direct association was found between the number of cardiovascular risk factors and the ApoB/ApoA1 ratio (p = 0.001), regardless of age and income. Conclusion: The increased ApoB/ApoA1 ratio was associated with excess weight, body adiposity (total and central), and altered lipid profile in children. Children with a higher number of cardiovascular risk factors had higher ApoB/ApoA1 ratio, in both genders.

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Castro, A. P. P., Hermsdorff, H. H. M., Milagres, L. C., Albuquerque, F. M. de, Filgueiras, M. de S., Rocha, N. P., & Novaes, J. F. de. (2019). Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children. Jornal de Pediatria, 95(2), 238–246. https://doi.org/10.1016/j.jped.2017.12.008

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