Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review

Abstract

Aim: The aim of this work was to perform a systematic literature review on the clinical application of rhBMP-2 in bone reconstruction prior to placing implants. Materials and Methods: A PUBMED search was made about the subject and nine clinical trials were selected according to strict inclusion criteria. Results: Overall success rates of bone regeneration with rhBMP-2 was 81.4% and success of implants placed was 87.4%. Most frequent adverse events were pain, edema and erythema. Conclusion: It was concluded that the treatment with rhBMP-2 foi satisfactory in most cases and the placement of dental implants in the bone regenerated with rhBMP-2 is feasible.