Isolation and Characterization of I5B2, a new Phosphorus Containing Inhibitor of Angiotensin I Converting Enzyme Produced by Actinomadura Sp.

Abstract

A new inhibitor of angiotensin I converting enzyme, I5B2, was isolated from the culture broth of Actinomadura sp. No. 937ZE-1. This compound contains N-methylvaline, tyrosine and l-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. The microorganism also produced another inhibitor, I5B1, which is identical with K-4 isolated from Actinomadura sp. as an antihypertensive agent. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.