Interaction of wild-type and naturally occurring deleted variants of hepatitis B virus core polypeptides leads to formation of mosaic particles

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Abstract

The simultaneous presence of hepatitis B virus (HBV) genomes carrying wild-type (wt) and in-frame deleted variants of the HBV core gene has been identified as a typical feature of HBV-infected renal transplant patients with severe liver disease. To investigate possible interactions of wt and deleted core polypeptides a two-vector Escherichia coli expression system ensuring their concomitant synthesis has been developed. Co-expression of wt and a mutant core lacking 17 amino acid residues (77-93) within the immunodominant region led to the formation of mosaic particles, whereas the mutant alone was incapable of self-assembly. Copyright (C) 2000 Federation of European Biochemical Societies.

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Preikschat, P., Kazaks, A., Dishlers, A., Pumpens, P., Krüger, D. H., & Meisel, H. (2000). Interaction of wild-type and naturally occurring deleted variants of hepatitis B virus core polypeptides leads to formation of mosaic particles. FEBS Letters, 478(1–2), 127–132. https://doi.org/10.1016/S0014-5793(00)01836-6

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