Small-bowel myeloid sarcoma: Report of a case with atypical presentation

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Abstract

INTRODUCTION Small-bowel myeloid sarcoma is rare. Acute bowel obstruction is its usual clinical presentation. PRESENTATION OF CASE We report a case of small-bowel myeloid sarcoma that occurred in a 64-year-old woman who presented chronic secretory diarrhoea, hypokalaemia, and weight loss. Immature white blood cells in a peripheral smear and small-bowel capsule endoscopic features were the main diagnostic clues. The patient experienced capsule retention and developed acute bowel obstruction. Urgent laparotomy showed a stricturing ileal mass and pathology of the resected bowel specimen unveiled a CD34+, CD117+, and myeloperoxidase-positive myeloid sarcoma. The diarrhoea promptly resolved after surgery, and the patient is now undergoing chemotherapy. DISCUSSION Secretory diarrhoea can be the first manifestation of small-bowel myeloid sarcoma. Capsule endoscopy may provide a diagnostic clue, but it can trigger an acute bowel obstruction. Differential diagnosis of the pathologic specimen may be difficult and a high suspicion index of is mandatory to perform immunophenotyping to determine the correct management. CONCLUSION Chronic diarrhoea with alarm features can be the first manifestation of small-bowel myeloid sarcoma. © 2014 The Authors.

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APA

Girelli, C. M., Carsenzuola, V., Latargia, M., Aguzzi, A., & Serio, G. (2014). Small-bowel myeloid sarcoma: Report of a case with atypical presentation. International Journal of Surgery Case Reports, 5(9), 613–616. https://doi.org/10.1016/j.ijscr.2014.07.002

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