From stones to bones: The biology of CIC chloride channels

27Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

Abstract

Chloride (Cl-) is the most abundant extracellular anion in multicellular organisms. Passive movement of Cl-through membrane ion channels enables several cellular and physiological processes including transepithelial salt transport, electrical excitability, cell volume regulation and acidification of internal and external compartments. One family of proteins mediating Cl- permeability, the CIC channels, has emerged as important for all of these biological processes. The importance of CIC channels has in part been realized through studies of inherited human diseases and genetically engineered mice that display a wide range of phenotypes from kidney stones to petrified bones. These recent findings have demonstrated many eclectic functions of CIC channels and have placed Cl- channels in the physiological limelight.

Cite

CITATION STYLE

APA

George, A. L., Bianchi, L., Link, E. M., & Vanoye, C. G. (2001). From stones to bones: The biology of CIC chloride channels. Current Biology, 11(15), R620–R628. https://doi.org/10.1016/S0960-9822(01)00368-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free