A comparison of buccal midazolam and intravenous diazepam for the acute treatment of seizures in children

9Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Objective: The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children. Methods: This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emergency department of a children's hospital. The primary outcome of this study was cessation of visible seizure activity within 5 minutes from administration of the first dosage. The second dosage was used in case the seizure remained uncontrolled 5 minutes after the first one. Findings: In the midazolam group, 22 (68.8%) patients were relieved from seizures in 10 minutes. Meanwhile, diazepam controlled the episodes of 42 (70%) patients within 10 minutes. The difference was, however, not statistically significant (P=0.9). The mean time required to control the convulsive episodes after administration of medications was not statistically significant (P=0.09). No significant side effects were observed in either group. Nevertheless, the risk of respiratory failure in intravenous diazepam is greater than in buccal midazolam. Conclusion: Buccal midazolam is as effective as and safer than intravenous diazepam in control of seizures. © 2012 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.

Cite

CITATION STYLE

APA

Tonekaboni, S. H., Shamsabadi, F. M., Anvari, S. S., Mazrooei, A., & Ghofrani, M. (2012). A comparison of buccal midazolam and intravenous diazepam for the acute treatment of seizures in children. Iranian Journal of Pediatrics, 22(3), 303–308. https://doi.org/10.1016/j.ejpn.2017.04.790

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free