Gold-catalyzed cyclizations of alkynol-based compounds: Synthesis of natural products and derivatives

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Abstract

The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium. © 2011 by The Authors.

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Alcaide, B., Almendros, P., & Alonso, J. M. (2011, September). Gold-catalyzed cyclizations of alkynol-based compounds: Synthesis of natural products and derivatives. Molecules. https://doi.org/10.3390/molecules16097815

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