Comparative context analysis of codon pairs on an ORFeome scale.

ISSN: 14656914
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Abstract

Codon context is an important feature of gene primary structure that modulates mRNA decoding accuracy. We have developed an analytical software package and a graphical interface for comparative codon context analysis of all the open reading frames in a genome (the ORFeome). Using the complete ORFeome sequences of Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida albicans and Escherichia coli, we show that this methodology permits large-scale codon context comparisons and provides new insight on the rules that govern the evolution of codon-pair context.

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Moura, G., Pinheiro, M., Silva, R., Miranda, I., Afreixo, V., Dias, G., … Santos, M. A. S. (2005). Comparative context analysis of codon pairs on an ORFeome scale. Genome Biology, 6(3).

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