Chemical Composition and Biological Activity of Paris quadrifolia L

Abstract

A study of the components of Paris quadrifolia was undertaken to identify compounds with potential influence on cardiac cells, since previous reports suggested a cardiotoxic risk of this plant. Compounds isolated and identified included one new steroidal saponin, (23S,24S)- spirosta-5,25(27)-diene-1β,3β,21,23,24-pentol-1-O-β-D-apiofuranosyl-(1å3)-a-L-rhamnopyranosyl-(1å2)-[β-D-xylopyranosyl-(1å3)]-β-D-glucopyranoside 21-O-β-D-apiofuranoside 24-O-β-D-fucopyranoside (1), demonstrating quite unusual structural features, as well as the known compounds 26-O-β-D-glucopyranosyl-(25R)-5-en-furost-3β,17α,22α,26-tetraol- 3-O-α-L-rhamnopyranosyl-(1å4)-α-L-rhamnopyranosyl-(1å4)-[a-L-rhamnopyranosyl- -(1å2)]-β-D-glucopyranoside (2), pennogenin 3-O-α-L-rhamnopyranosyl-(1Ar4)-α-L-rham- nopyranosyl-(1å4)-[a-L-rhamnopyranosyl-(1 2)]-β-D-glucopyranoside (3), 7-O-β-D-glucopyranosyl-kaempferol-3-O-β-D-glucopyranosyl-(1å2)-β-D-galactopyranoside (4), kaempferol-3-O-β-D-glucopyranosyl-(1å2)-β-D-galactopyranoside (5), 5-hydroxyecdysterone (6), and 20-hydroxyecdysone (7). The pennogenin derivative 3 showed strong cardiotoxic effects in an in vitro cellular model system, whereas the respective furostanol derivative 2 was inactive. © 2012, Verlag der Zeitschrift für Naturforschung. All rights reserved.