Nutritional anaemia in pregnant Beninese women: consequences on the haematological profile of the newborn

Abstract

1. An assessment of iron and folic acid status, blood thick film and haemoglobin (Hb) electrophoresis was performed on 126 pregnant women (and their newborn infants) and in ninety-five menstruating women in Cotonou (Benin).2. Anaemia (according to the World Health Organization (1972)) was observed in 55% of pregnant women and in 39% of menstruating women.3. Fe-deficiency was defined as a low serum ferritin concentration (12μg/l or less), combined with a low transferrin saturation (less than 16%) or a high erythrocyte protoporphyrin level (more than 3 μg/g Hb), or both. A moderate elevation in the serum ferritin concentration (between 13 and 50 μg/l), associated with a low transferrin saturation or a high erythrocyte protoporphyrin level, or both, indicated Fe-deficiency in an inflammatory context. Fe-deficiency was present in 73% of pregnant women and in 41% of menstruating women.4. Folate deficiency (defined as erythrocyte folate below 160 μg/l) was observed in 45% of pregnant women.5. In pregnant women, anaemia was associated with Fe-deficiency in 83% of cases and with folate deficiency in 48% of cases. 6. Haemoglobinopathies were mainly heterozygous and did not seem to contribute significantly to anaemia. Intensity of malaria was not related to Hb level, but Plasmodium falcipurum was found in 99% of subjects. 7. Hb concentration and mean corpuscular volume were significantly lower in babies born of Fe-deficient mothers than in babies born of Fe-sufficient mothers. Hb concentration in newborn infants was positively correlated with maternal serum ferritin.