Autophagosomes are formed at a distinct cellular structure

0Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes, which deliver bulk cytoplasmic material to the lytic compartment of the cell for degradation. Autophagosome formation is initiated by assembly and recruitment of the core autophagy machinery to distinct cellular sites, referred to as phagophore assembly sites (PAS) in yeast or autophagosome formation sites in other organisms. A large number of autophagy proteins involved in the formation of autophagosomes has been identified; however, how the individual components of the PAS are assembled and how they function to generate autophagosomes remains a fundamental question. Here, we highlight recent studies that provide molecular insights into PAS organization and the role of the endoplasmic reticulum and the vacuole in autophagosome formation.

Cite

CITATION STYLE

APA

Hollenstein, D. M., & Kraft, C. (2020, August 1). Autophagosomes are formed at a distinct cellular structure. Current Opinion in Cell Biology. Elsevier Ltd. https://doi.org/10.1016/j.ceb.2020.02.012

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free