Practical enantioselective reduction of ketones using oxazaborolidine catalysts generated in situ from chiral lactam alcohols

13Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Oxazaborolidine catalyst (CBS catalyst) has been extensively used for catalytic borane reduction with a predictable absolute stereochemistry and high enantioselectivity. However, the use of isolated CBS catalyst sometimes has the drawback of low reproducibility due to the aging of the CBS catalyst during storage. Therefore, we investigated a more reliable and practical method for the reduction of a variety of ketones including challenging substrates, primary aliphatic ketones, a,ß-enones, and trifluoromethyl ketones. This review surveys the developments in borane reduction using oxazaborolidine catalysts generated in situ from chiral lactam alcohols and borane.

Cite

CITATION STYLE

APA

Kawanami, Y., & Yanagita, R. C. (2018, September 20). Practical enantioselective reduction of ketones using oxazaborolidine catalysts generated in situ from chiral lactam alcohols. Molecules. MDPI AG. https://doi.org/10.3390/molecules23102408

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free