Although events associated with replication stress have long formed the cornerstone of checkpoint activation, questions remain about how cells maintain the integrity of replicating genomes. Now, Bermejo et al. (2011) identify a mechanism directly linking checkpoint function to the relief of topological tension at nuclear pore tethered genes. © 2011 Elsevier Inc.
Lukas, J., & Bartek, J. (2011, July 22). Tethered genes get checked during replication. Cell. Cell Press. https://doi.org/10.1016/j.cell.2011.06.046