Sequence conservation in the α and β subunits of pyruvate dehydrogenase and its similarity to branched-chain α-keto acid dehydrogenase

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Abstract

Amino acid sequence comparison of 8α and 6β subunits of the α-keto acid dehydrogenase (E1) component of the pyruvate dehydrogenase complex and branched-chain α-keto acid dehydrogenase complex from multiple species was performed by computer analysis. In addition to 2 previously recognized regions of homology in the α subunit, a 3rd region of extensive homology was identified in E1α, and may be one of the sites involved in subunit interaction. E1β contains 4 regions of extensive homology. Region 1 contains 10 amino acids that are homologous to a 10-amino acid stretch in Escherichia coli E1. Regions 2 and 3 have sequence homologies with other dehydrogenases suggesting that these regions may be involved in catalysis. © 1991.

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Wexler, I. D., Hemalatha, S. G., & Patel, M. S. (1991). Sequence conservation in the α and β subunits of pyruvate dehydrogenase and its similarity to branched-chain α-keto acid dehydrogenase. FEBS Letters, 282(1), 209–213. https://doi.org/10.1016/0014-5793(91)80479-M

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