Assay for the Quantitative Estimation of the Gonadotropin Inhibiting Material in Human Urine

Abstract

A method for the quantitative estimation of the gonadotropin inhibiting material (GIM) in human urine is standardised using the ovarian ascorbic acid depletion test, the results being expressed in terms of and HCG units. A dose-response relationship with GIM is established. The reliability of the assay is demonstrated. Unlike other methods of assay this method is able to express precisely the quantity of GIM present in the urine. Preliminary data on GIM values in normal subjects as well as patients with endocrine disorders are presented. © 1974, The Japan Endocrine Society. All rights reserved.