Objectives: Chronic urticaria (CU) (or chronic hives) can be inducible or spontaneous (also known as idiopathic urticaria) (CSU/CIU). Data supporting the impact of CSU/CIU on patients and comparison with other dermatological diseases are scarce. This study evaluated humanistic burden associated with CU relative to psoriasis (PsO) and different severity of PsO among the adults in 5 European (France, Germany, Italy, Spain and UK) countries. Methods: Data come from diagnosed CU (proxy for CSU) and PsO patients collected in the National Health and Wellness Survey (NHWS). Humanistic burden was measured through the mental and physical component score (MCS, PCS) of the SF-36v2 and SF-6D health utility score. Self-reported anxiety, depression and sleep difficulty were also assessed. NHWS collects data on PsO severity but not on CU severity. Multiple linear or logistic regressions was used to compare outcomes between patients with CU vs. overall PsO (included all severity levels) and CU vs. moderate-severe-PsO, controlling for patient characteristics. Results: Study included 769 CU patients and 7,857 PsO patients (26.9% moderate-severe). CU patients had lower (worse) MCS (mean±SE, 42.2±0.39 vs. 44.6±0.16), PCS (45.2±0.34 vs. 46.8±0.14) and SF-6D score (0.65±0.005 vs. 0.68±0.002) than overall PsO (all p< 0.001). Scores for moderate-severe-PsO were 43.2±0.25 (p< 0.05), 45.7±0.22 (p= NS) and 0.667±0.003 (p< 0.05) respectively. CU patients had higher adjusted odds of anxiety, depression and sleep difficulties than overall PsO [odds ratio (OR):1.63, 1.34 and 1.56, respectively, all p< 0.01]. There was no significant difference between moderate-severe-PsO (OR: 1.45, 1.12, and 1.36, respectively) and CU patients for the same parameters. Conclusions: CU and PsO have a negative impact on patients' quality of life. CU patients report significantly higher impairment and more psychological complaints than overall PsO patients. When compared to moderate-severe-PsO, patients with CU still have a significantly slightly higher impairment in mental status and lower utility and similar physical impairment and psychological complaints.
Tian, H., Vietri, J., Gabriel, S., Karagiannis, T., & Balp, M. (2015). Humanistic Burden of Chronic Spontaneous Urticaria In Comparison to Psoriasis: US And European Perspective. Value in Health, 18(3), A176. https://doi.org/10.1016/j.jval.2015.03.1017