GPCR Signaling: The Interplay of Gαi and β-arrestin

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Abstract

Biased agonism at G-protein-coupled receptors is generally conceptualized as the ability of certain stimuli to trigger downstream signaling exclusively through one of two effectors. Recent studies reveal that signaling downstream of the β1 adrenergic receptor and the angiotensin II type 1 receptor induced by biased stimuli actually involves both effectors. Biased agonism at G-protein-coupled receptors is generally conceptualized as the ability of certain stimuli to trigger downstream signaling exclusively through one of two effectors. Recent studies reveal that signaling downstream of the β1 adrenergic receptor and the angiotensin II type 1 receptor induced by biased stimuli actually involves both effectors.

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Dwivedi, H., Baidya, M., & Shukla, A. K. (2018, April 2). GPCR Signaling: The Interplay of Gαi and β-arrestin. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2018.02.027

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