Mitophagy, a process of selective elimination of mitochondria by autophagy, is a mechanism of mitochondrial quality control that maintains mitochondrial network functionality. The elimination of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Mitophagy impairment is linked to various pathologies; thus, removal of malfunctioning or even harmful mitochondria is vital to cellular physiology. Here, we describe methods that can be applied to the investigation of mitophagy.
CITATION STYLE
Yapryntseva, M. A., Zhivotovsky, B., & Gogvadze, V. (2022). Induction and Detection of Mitophagy. In Methods in Molecular Biology (Vol. 2445, pp. 227–239). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2071-7_14
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