Control of proliferation by Bcl-2 family members

0Citations
Citations of this article
60Readers
Mendeley users who have this article in their library.

Abstract

The anti-proliferative effect of Bcl-2 acts mainly at the level of the G0/G1 phase of the cell cycle. Deletions and point mutations in the bcl-2 gene show that the anti-proliferative activity of Bcl-2, can in some cases, be dissociated from its anti-apoptotic function. This indicates that the effect of Bcl-2 on cell cycle progression can be a direct effect and not only a consequence of its anti-apoptotic activity. Bcl-2 appears to mediate its anti-proliferative effect by acting on both signal transduction pathways (NFAT, ERK) and on specific cell cycle regulators (p27, p130). © 2003 Elsevier B.V. All rights reserved.

Author supplied keywords

Cite

CITATION STYLE

APA

Bonnefoy-Berard, N., Aouacheria, A., Verschelde, C., Quemeneur, L., Marçais, A., & Marvel, J. (2004, March 1). Control of proliferation by Bcl-2 family members. Biochimica et Biophysica Acta - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2003.10.014

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free