Biological activities of toxins A and B of Clostridium difficile

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Abstract

Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.

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Lyerly, D. M., Lockwood, D. E., Richardson, S. H., & Wilkins, T. D. (1982). Biological activities of toxins A and B of Clostridium difficile. Infection and Immunity, 35(3), 1147–1150. https://doi.org/10.1128/iai.35.3.1147-1150.1982

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