Abstract
The 3= end of rsbU, encoding the positive regulator of the stress factor sigma B, was identified as a hot spot for spontaneous IS256 insertion in Staphylococcus aureus SA137/93G. Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU:: IS256 insertion mutants. In consequence of the inactivation of rsbU, the IS256 transposition frequency was increased 4-fold in S. aureus HG001. Copyright © 2013 White.
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CITATION STYLE
Schreiber, F., Szekat, C., Josten, M., Sahl, H. G., & Bierbaum, G. (2013). Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 57(12), 6381–6384. https://doi.org/10.1128/AAC.01585-13
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