FP296NONINVASIVE ASSESSMENT OF RENAL FIBROSIS BY SHEAR WAVE ELASTOGRAPHY

Abstract

Introduction and Aims: Renal fibrosis is an important risk factor for the progression of chronic kidney disease. Shear wave elastography (SWE) is a novel noninvasive technique to evaluate tissue fibrosis. The aim of our study was to investigate the usefulness of SWE for the assessment of renal fibrosis in kidney biopsies. Methods: Patients hospitalized in our nephrology clinic and who underwent renal biopsy between February 2012‐June 2014 were recruited to the study. Patient demographic, clinical and laboratory data were obtained from the patients' file. The elastographic study was performed with sonoelastographic device using 4 mhz transducer SSI(Aixplorer; SuperSonic Imgine, Les Jardins De La Duranne, Aix en Provence. France ) before kidney biopsy. Signals from the inferior pole of the kidney cortex using a shear wave elastography was evaluated according to color scale in Tsukuba score and expressed as kilopascal (kPa). Biopsies of patients were evaluated by the same pathologist who is specialized in Nephropathology. Patients were grouped according to presence or absence of fibrosis in kidney biopsy. SWE findings were compared in these groups Results: Fifty six patients were included the study. The demographic characteristics and laboratory data for the patients are shown in Table 1. The elastograhic measurements was significantly higher in patients with fibrosis in kidney biopsies (p=0.046). The elastograhic measurements showed no significant relation with urea, creatinine, GFR and proteinuria (Table 2). Conclusions: In this study a significant relation is found between fibrosis in pathologic investigation and elastograhic measurements. This method seems to be a valuable method for the detection of the status of the renal fibrosis. (Table Presented).